The Chemistry of the Liver in Chloroform Necrosis (Delayed Chloroform Poisoning)

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The Chemistry of the Liver in Chloroform Necrosis (delayed Chloroform Poisoning)

Recently I reported the results of a complete analysis of a liver exhibiting the typical conditions of acute yellow atrophy,’ and while engaged in this analysis had the good fortune, through the kindness of Dr. F. S. Tufts, to perform an autopsy upon the body of a young man who had died a few hours before from the condition of acute necrosis of the liver that occasionally follows the administra...

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Delayed Chloroform Poisoning

Sir,?As no comment has been made on the interesting paper 011 " Delayed Chloroform Poisoning" by Major Munro and Capt. Denham White which appeared in the October issue of the Indian Medical Gazette, I shall be grateful if you will grant me space for a few remarks 011 this very important subject. Frew (1) has shown that of 662 children admitted for all causes to the hospital for sick children, G...

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Clinical evidence for delayed chloroform poisoning.

From its introduction in 1847, chloroform proved to be a potent anaesthetic agent and over the next 50 yr its use became widespread. However, in 1912 the Committee on Anaesthesia of the American Medical Association stated that they were concerned with the occurrence of delayed chloroform poisoning in a number of cases. This conclusion was based on case reports and experimental animal data. Howe...

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Chloroform Poisoning

Sir,?I have recently returned to a well-known firm of druggists in Rangoon a consignment of chloroform which was labelled chloloform pure B. P. (made from pure alcohol dbc." It appeared to take an excessive amount to ansesthetise : patients became very cyanotic with irregular breathing: the pulse was often weak : and many had much vomiting, and felt very ill for two days. A sample was sent to t...

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Fibrinogen of the Blood as Influenced by the Liver Necrosis of Chloroform Poisoning

1. Chloroform anesthesia for two hours or more will cause more or less central liver necrosis in dogs, depending on the length of the anesthesia and the susceptibility of the animal. 2. If the fibrinogen of the blood of such an animal be estimated at intervals, it is found that this proteid shows a drop corresponding to the amount of liver necrosis. 3. By administering chloroform, the fibrinoge...

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ژورنال

عنوان ژورنال: Journal of Biological Chemistry

سال: 1908

ISSN: 0021-9258

DOI: 10.1016/s0021-9258(18)91682-0